Macrohon was weaned from the jurisdiction of Maasin in 1904. After the United States took over the Philippines from Spain, Macrohon became a municipality. However, in 1906, it was reverted as a barrio. When Salvador Demetrio was elected delegate to the First National Assembly in 1907, he made Macrohon a municipality.
Distinguished luminaries from Macrohon are World War II resistance hero, Col. Ruperto K. Kangleon who was also a secretary of National Defense and Senato,. Representative Ciriaco K. Kangleon, Leyte Governor Salvador Demetrio, Arch-bishop Mariano D. Gaviola, and Court of Appeals judge Ramon G. Gaviola Jr..